Sulfuric acid is very corrosive and would badly burn any plants, birds or land animals exposed to it. Synthesis of Aspirin Synthesis Purification Characterization . The synthesis of aspirin is classified as an esterification reaction. One of the oldest drugs! Aspirin Synthesis Experiment 5. It dissolves when mixed with water. Antipyretic (fever reducer)! Your aspirin product as well as a commercial aspirin tablet will be compared to a standard 0.15% ferric-salicylate solution. This process yields aspirin and acetic acid, which is considered a byproduct of this reaction.

The Synthesis and Analysis of Aspirin Mariam El-Magbri Department of Chemistry, American University, Washington, D.C. 20016 Date of Publication: February 26, 2014 ABSTRACT: Acetylsalicylic acid commonly known as aspirin is the most widely used drug in the world today. Analgesic (painkiller)! The temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water. Most of us are familiar with esters, but are not aware of their presence in our everyday life. Its analgesic, antipyretic, and anti-inflammatory properties make it a powerful and effective drug to relive symptoms … One of the most consumed drugs (Production in the US is 10 million Kg/year) Aspirin: Biological activity! It has moderate acute (short-term) toxicity on aquatic life. Aspirin: some background!

The role of sulphuric acid in the synthesis of aspirin is of a catalyst, and it is also a source of protons for carrying out the esterification of salicylic acid with acetic anhydride.

2 The spectroscopic analysis of aspirin will involve the complexing of iron(III) to the deprotonated form of salicylic acid (salicylate ion) to give a purple solution. Anti-inflammatory (inhibition of the synthesis of prostaglandins)! Esterification: The Synthesis of Aspirin (ASA) Introduction . ASPIRIN SYNTHESIS AND MECHANISM Synthesis. In the process of aspirin synthesis mechanism, the protons of the acid reacts with the acetic anhydrate to bond with both oxygen with double bond and in between the acetate groups. Patented by Bayer in 1893! Salicylic acid is treated with acetic anhydride, an acid derivative, causing a chemical reaction that turns salicylic acid's hydroxyl group into an ester group (R-OH → R-OCOCH 3).

Sulfuric acid will exist as particles or droplets in the air if released to the atmosphere. Only the salicylate ion complexes to iron(III). For the sake of time and efficiency, sulfuric acid was added as a catalyst to speed up the reaction. Reactions: Procedure and Results: Aspirin Synthesis Tap water was heated on a steam bath in a 250 mL beaker. Aspirin is synthesized through a mechanism, now called aspirin synthesis mechanism. Synthesis of acetylsalicylic acid (Aspirin): • Synthesis / working-up • HPLC (reaction control /purity control) Experimental arrangement: Mechanism of the reaction: • addition-elimination- mechanism O O H O H O O O H + O O H O O H O O + + lone pair nucleophile high electron density electrophilic carbon low electron density δ+ δ-1. Synthesis of Aspirin By: Jon Torre Purpose: To determine which of four catalysts yields the fastest reaction rate in the acetylation of salicylic acid (1) to form acetylsalicylic acid (2).

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